Local: 763-447-2500 TOLL FREE: 866-219-4699 Have a question?


The LIPOPPS™ procedure, which uses the FDA-registered PRISM PARTICLE SIZER™ device to create precision sized 0.3mm diameter micro-fragmented adipose tissue (MFAT), is a revolutionary adipose regenerative treatment that may supersede predecessor technologies for the repair, regeneration, and replacement of injured musculoskeletal tissue

Lipopps™ Procedure Overview

Adipose-derived stem cells are abundant in human adipose tissue. Harvested adipose tissue serves as an abundant source of regenerative cell populations for the repair, regeneration, and replacement of injured or degenerative tissues.

The above photo shows the PRISM PARTICLE SIZERdevice (Model# PPS-D-300) capable of processing harvested lipo aspirate tissue into 0.3mm micro-fragmented adipose tissue (MFAT) particles to be used as an injectable biologic agent for musculoskeletal regenerative medicine treatments.

The Lipopps™ procedure was developed by regenerative medicine specialist, Roger Hogue, MD, at HOGUE CLINICS. While conventional lipo harvesting technology is used to harvest adipose tissue, the PRISM PARTICLE SIZER™ (also known as PPS), is used to decremental size and process the harvested adipose tissue into micro-fragmented adipose tissue, abbreviated as MFAT. Depending on physician choice, currently available commercial PPS devices allow for 0.2 mm or 0.3mm or 0.4mm dimensional adipose particles to be prepared for injection as biologic agents for deployment into targeted musculoskeletal areas of injury or degeneration. The Lipopps™ procedure was named by its inventor, Dr. Hogue, by combining “LIPO” with the abbreviation for PRISM PARTICLE SIZER™, “PPS“, to create “LIPOPPS” .

At HOGUE CLINICS, the Lipopps™ procedure is performed while awake on patients with painful, degenerative musculoskeletal conditions, especially the knees and shoulders. The Lipopps™ procedure may also be performed on injured or degenerative tendons, ligaments, and muscles following a consultation and evaluation with Dr. Hogue.

Ideal Candidate for Lipopps™ Procedure

The Lipopps™ procedure at HOGUE CLINICS for treatment of painful, degenerative orthopedic conditions is ideal for certain patients including:

  • Patients with painful osteoarthritis affecting their knees, shoulders, or other peripheral joints (excluding hips, back, neck or spine)
  • Patients looking to avoid surgical joint replacement surgery
  • Patients with injured or degenerative tendons, ligaments, muscles

Regenerative medicine specialist Dr. Hogue will perform a thorough history and physical exam to determine each individual patient’s candidacy for the Lipopps™ procedure.

Many supportive studies in support of the clinical use of MFAT in humans suffering from osteoarthritis (knees, shoulders) have recently been published in the scientific literature.

Publications on MFAT injections for knees:









Publications on MFAT injections for shoulders:




How is Lipopps™ Procedure Performed?

With the Lipopps™ procedure, awake, minimally-invasive tumescent liposuction is first performed in office to harvest an adequate amount of adipose tissue from the patient’s body, usually from the abdomen, flanks, or thighs. Oral sedation with lorazepam (Ativan), inhaled nitrous oxide (ProNox), and local anesthesia are often used to enhance patient comfort. After the harvested fat is washed, then gravity decanted to remove impurities, the harvested adipose clusters are processed using the PRISM PARTICLE SIZER™ device and without jeopardizing the adipose tissue structure or function. This process creates autologous (self-derived) micro precision-sized micro-fragmented adipose tissue (MFAT). Depending on physician selection, 0.2mm or 0.3mm or 0.4mm dimensional adipose particles of MFAT can be injected into targeted musculoskeletal areas as an autologous fat transfer procedure using tiny 22-gauge to 23-gauge needles to initiate regenerative tissue healing. The entire Lipopps™ procedure takes about 90-120 minutes to perform.

Expectations after Lipopps™ Procedure?

Patients undergoing the Lipopps™ procedure can expect pain, bruising, swelling, drainage, and soreness at the lipo harvesting area. For several days, the musculoskeletal injection sites may bruise, bleed, swell, or remain achy and sore. Since regenerative medicine treatments rely on the body’s natural healing mechanism, it is important to avoid aspirin, NSAIDS, and corticosteroids for several weeks, unless there is a need to commence these medications sooner for other medical reasons. Avoidance of strenuous activities for 1-2 weeks is also advisable.

Clinical results following the Lipopps™ procedure can take several months up to a year to reach maximal results. Additional, supplemental treatments with biologic agents such as PRP may be recommended after a Lipopps™ procedure, if clinically indicated, to further along regenerative healing and tissue regeneration.

Individual results following regenerative medicine treatments at HOGUE CLINICS may vary from individual to individual. Clinical post-procedure recovery and return to functionality may also vary.

How much is the Lipopps™ Procedure?

HOGUE CLINICS charges $2500 for the Lipopps™ procedure to treat a single knee, or shoulder, or other peripheral joint (or tendon or ligament or muscle). The self-pay rate for additional Lipopps™ musculoskeletal treatments are $700 each per treatment area, provided they are done during the initial procedure. Pricing includes pre-op visit, pre-op labs, entire surgical and facility fee, anesthesia, and all relevant follow-up visits for up to 1-year at HOGUE CLINICS. The Lipopps™ procedure is not covered by Medicare or by private insurance companies currently. Additional charges would be incurred if other biologic agents such as PRP or MSC Exosomes are used along with the Lipopps™ procedure.

Free Consultation

Call HOGUE CLINICS today to schedule your complimentary consultation with Dr. Hogue to discuss the Lipopps™ procedure.

Schedule a FREE

Contact Us



7365 Kirkwood Court North Suite 120, Maple Grove, MN55369

(763) 447-2500

Get Directions